Cardiovascular & clot risk

Simplified PESI (sPESI)

Six-item mortality-risk stratification after pulmonary embolism is diagnosed.

Intended population: Adults with confirmed acute PE; use with hemodynamics, right-ventricular assessment, biomarkers, and feasibility of care.

A score of 0 alone does not establish suitability for outpatient treatment. Assess oxygen/analgesia needs, bleeding risk, RV dysfunction, biomarkers, comorbidity, and support.
Use after PE diagnosis, not to diagnose or exclude PE. Clinical instability overrides the score.

Adult with confirmed acute PE

Age (years)

History of cancer

Chronic heart failure OR chronic pulmonary disease

Heart rate (beats/min)

Systolic blood pressure (mmHg)

Oxygen saturation (%)

Hemodynamic instability, shock, or other indication for emergency escalation

Sources and scoring references

Jiménez et al.: original simplified PESI study ↗2026 AHA/ACC multisociety acute PE guideline ↗

Implementation references reviewed October 28, 2026. Verify applicability and unusual or treatment-changing results against the linked references and local guidance.